Paper I
2023 January (Supplementary) (2019 Scheme) · 100 marks · 180 min

Question

Enumerate four therapeutic uses of Adrenaline, with its rationale for use in each condition.

Q94 marksShort Answers

Answer

  • Anaphylactic shock — drug of choice; alpha-1 action reverses hypotension, beta-2 action relieves bronchospasm, and beta-1 action supports cardiac output, simultaneously reversing every major life-threatening component of the reaction.
  • Cardiac arrest — beta-1-mediated increase in heart rate/contractility and alpha-1-mediated vasoconstriction (raising coronary/cerebral perfusion pressure during CPR) help restore spontaneous circulation.
  • Added to local anesthetics — alpha-1-mediated vasoconstriction at the injection site reduces systemic absorption, prolonging local anesthetic action and reducing bleeding.
  • Acute severe asthma (refractory to inhaled bronchodilators) — beta-2-mediated bronchodilation, given when inhaled therapy is inadequate or inaccessible.

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