Paper I
2022 July (Supplementary) (2019 Scheme) · 100 marks · 180 min

Question

Prazosin/Tamsulosin in Benign Prostatic Hypertrophy. Name the following (Two examples for each): (8x1=8)

Q140.2 marksShort Answers

Answer

Tamsulosin is the appropriate choice — selective for alpha-1A receptors, which predominate in the bladder neck and prostatic smooth muscle, relieving obstructive urinary symptoms with minimal effect on vascular alpha-1 receptors and therefore little hypotension. Prazosin, a non-selective alpha-1 blocker, is also effective in BPH but carries a substantially greater risk of postural hypotension and dizziness (also requiring dose titration), making tamsulosin the more uroselective and better-tolerated choice specifically for BPH.

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