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Paper I — 2018 July (Supplementary) (2010 Scheme) — Q10

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Paper I
2018 July (Supplementary) (2010 Scheme) · 40 marks · 120 min

Question

Rationale for use of prazosin in benign prostatic hyperplasia

Q101 marksShort Answers

Answer

Prazosin is a selective α1-adrenergic receptor antagonist. In BPH, α1 receptors in the smooth muscle of the prostate capsule, prostatic urethra, and bladder neck contribute to the dynamic component of bladder outlet obstruction. By blocking these receptors, prazosin relaxes prostatic/urethral smooth muscle, reducing urethral resistance and improving urine flow — providing rapid symptomatic relief without reducing prostate size.

  1. 1Adrenergic System

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