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Paper II — 2019 July (Supplementary) (2010 Scheme) — Q8

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Paper II
2019 July (Supplementary) (2010 Scheme)

Question

Propranolol in thyroid storm

Q81 marksShort Answers

Answer

In thyroid storm, excessive circulating thyroid hormone produces severe sympathetic overactivity (tachycardia, hyperthermia, tremor, agitation) due to increased tissue sensitivity to catecholamines. Propranolol, a non-selective beta blocker, rapidly controls these adrenergic symptoms by blocking β1-mediated cardiac effects, providing prompt symptomatic relief while definitive antithyroid therapy takes effect. It also has the added benefit of inhibiting peripheral conversion of T4 to the more active T3, providing some direct antithyroid benefit as well.

  1. 1Adrenergic System

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