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Paper I — 2013 April (2010 Scheme) — Q5

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Paper I
2013 April (2010 Scheme) · 40 marks · 180 min

Question

Kinetics of elimination

Q53 marksShort Notes

Answer

Elimination of drugs follows one of two kinetic patterns:

First-order kinetics

  • A constant fraction of the drug is eliminated per unit time
  • Rate of elimination is proportional to plasma drug concentration
  • Plasma concentration falls exponentially with time; a semilog plot of concentration vs. time is linear
  • Has a constant half-life (t½), independent of dose/concentration
  • Most drugs at therapeutic doses follow first-order kinetics

Zero-order kinetics

  • A constant amount of drug is eliminated per unit time, independent of plasma concentration
  • Occurs when the elimination pathway (usually an enzyme) is saturated
  • Plasma concentration falls linearly with time
  • Half-life is not constant — it increases with dose
  • Examples: Phenytoin, Ethanol, Aspirin (at high/toxic doses)

Clinical significance

  • Drugs with zero-order kinetics show disproportionate rise in plasma levels with small dose increments, making dose titration critical and toxicity more likely (e.g., phenytoin)
  1. 1Pharmacokinetics

Other Years Asked

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  2. 2Discuss the factors modifying drug action. Describe the clinical importance of plasma protein binding of drugs. (4+4)2024 June (Supplementary) (2019 Scheme)Short Essay · 8 marks
  3. 3Briefly describe kinetics of elimination. Add a note on factors modifying drug action. (4+4)2023 January (Supplementary) (2019 Scheme)Short Essay · 8 marks
  4. 4Briefly describe drug biotransformation. Describe microsomal enzyme induction. (4+4)2023 July (Supplementary) (2019 Scheme)Short Essay · 8 marks
  5. 5Define bioavailability. What are the factors that affect bioavailability of drugs (1+5)2024 December (Supplementary) (2019 Scheme)Short Essay · 6 marks
  6. 6Briefly describe kinetics of elimination.2025 March (Supplementary (SAY)) (2019 Scheme)Short Answer · 4 marks
  7. 7Briefly describe enzyme induction and enzyme inhibition with suitable examples.2024 March (Supplementary) (2019 Scheme)Short Answer · 4 marks
  8. 8Contra indications and drug interactions of oral contraceptive pills.2025 March (Supplementary (SAY)) (2019 Scheme)Short Answer · 4 marks
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  10. 10First pass metabolism.2016 October (Supplementary) (2010 Scheme)Short Note · 3 marks
  11. 11Desferrioxamine2018 July (Supplementary) (2010 Scheme)Short Note · 3 marks
  12. 12Microsomal enzyme induction2013 September (Supplementary) (2010 Scheme)Short Note · 3 marks
  13. 13Plasma half life2018 February (2010 Scheme)Short Note · 3 marks
  14. 14Define half life of a drug and give its clinical significance2024 August (Supplementary) (2010 Scheme)Short Note · 3 marks
  15. 15Adverse effects of oral contraceptives2015 February (2010 Scheme)Short Note · 3 marks
  16. 16Plasma half-life2014 March (2010 Scheme)Short Note · 3 marks
  17. 17Bioavailability.2016 February (2010 Scheme)Short Note · 3 marks
  18. 18Apparent volume of distribution2019 February (2010 Scheme)Short Note · 3 marks
  19. 19First pass metabolism2019 July (Supplementary) (2010 Scheme)Short Note · 3 marks
  20. 20Pharmacogenetics2021 February (Supplementary) (2010 Scheme)Short Note · 3 marks
  21. 21Plasma half life2021 December (Supplementary) (2010 Scheme)Short Note · 3 marks
  22. 22Insulin Glargine2019 February (2010 Scheme)Short Note · 3 marks
  23. 23Dipivefrine2017 February (2010 Scheme)Short Answer · 1 mark
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  25. 25Low dose ritonavir2018 July (Supplementary) (2010 Scheme)Short Answer · 1 mark
  26. 26Select the CORRECT statement regarding protein binding of drugs: 1. Protein bound drug is not available for action. 2. Highly plasma protein bound drugs tend to have high volume of distribution. 3. Highly protein bound drugs are generally long acting. 4. Basic drugs are generally bound to albumin.2024 December (Supplementary) (2019 Scheme)MCQ · 1 mark
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  28. 28Enzyme inducers2014 March (2010 Scheme)Short Answer · 1 mark
  29. 29Imipenem with cilastatin2021 December (Supplementary) (2010 Scheme)Short Answer · 1 mark
  30. 30The following insulin is preferred to be given intravenously in diabetic ketoacidosis:2024 December (Supplementary) (2019 Scheme)MCQ · 1 mark
  31. 31Ritonavir in low doses in various Anti retroviral regimes2024 August (Supplementary) (2010 Scheme)Short Answer · 1 mark
  32. 32The Dopamine agonists used to treat Parkinson’s disease are:2025 March (Supplementary (SAY)) (2019 Scheme)MCQ (Multi) · 1 mark
  33. 33Plasma half life and its clinical relevance.2016 February (2010 Scheme)Short Answer · 1 mark
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  36. 36Oral anticoagulants2018 July (Supplementary) (2010 Scheme)Short Answer · 1 mark
  37. 37The following statements about iron kinetics is FALSE:2024 December (Supplementary) (2019 Scheme)MCQ · 1 mark
  38. 38Atracurium2018 February (2010 Scheme)Short Answer · 1 mark
  39. 39Causing peripheral neuritis2018 July (Supplementary) (2010 Scheme)Short Answer · 1 mark
  40. 40Comment on the drug interaction produced by sulfonylureas and salicylates.2013 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  41. 41Pro drugs2017 August (Supplementary) (2010 Scheme)Short Answer · 1 mark
  42. 42Chemical antagonism with one example.2014 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  43. 43The factor which does not govern the volume of distribution of a drug is2024 December (Supplementary) (2019 Scheme)MCQ · 1 mark
  44. 44Hofmann elimination2013 April (2010 Scheme)Short Answer · 1 mark
  45. 45The WRONGLY paired drug and its influence on thyroid function is:2024 December (Supplementary) (2019 Scheme)MCQ · 1 mark
  46. 46Imipenem and cilastatin2021 February (Supplementary) (2010 Scheme)Short Answer · 1 mark
  47. 47What is a pro drug and mention two examples2013 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  48. 48The drug safe in pregnancy2025 March (Supplementary (SAY)) (2019 Scheme)MCQ (Multi) · 1 mark
  49. 49Glipizide in elderly patients2022 May (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  50. 50Microsomal enzyme inducers2019 July (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  51. 51Anti-fungal azole derivative2021 December (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  52. 52Atypical neuroleptics2021 December (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  53. 53Prodrugs2022 October (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  54. 54Prodrugs.2025 March (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
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  57. 57Drugs having high first pass metabolism2024 March (Supplementary) (2019 Scheme)Short Answer · 0.2 marks
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  59. 59Prodrugs.2023 July (Supplementary) (2019 Scheme)Short Answer · 0.2 marks

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