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Paper II — 2022 May (Supplementary) (2010 Scheme) — Q14

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Paper II
2022 May (Supplementary) (2010 Scheme)

Question

Glibenclamide/Glipizide in elderly patients

Q140.3 marksShort Answers

Answer

Glipizide is the appropriate choice — a shorter-acting sulfonylurea with no active metabolites, giving a lower risk of prolonged or severe hypoglycemia in elderly patients. Glibenclamide has a longer duration of action and active metabolites that can accumulate (particularly with age-related decline in renal function), carrying a substantially higher risk of severe, prolonged hypoglycemia in the elderly — making it a poor choice in this age group.

  1. 1Pharmacokinetics

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