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Paper I — 2018 February (2010 Scheme) — Q12

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Paper I
2018 February (2010 Scheme) · 40 marks · 120 min

Question

Atracurium

Q121 marksShort Answers

Answer

Atracurium is a non-depolarizing (competitive) neuromuscular blocker. It competitively blocks nicotinic receptors at the neuromuscular junction. Its unique feature is elimination by Hofmann elimination — spontaneous, non-enzymatic degradation at physiological pH and temperature — making its duration of action independent of hepatic or renal function, which is useful in patients with liver or kidney failure. Its action can be reversed by anticholinesterases (e.g., neostigmine).

  1. 1Pharmacokinetics

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