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Paper I — 2024 March (Supplementary) (2019 Scheme) — Q17

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Paper I
2024 March (Supplementary) (2019 Scheme) · 100 marks · 180 min

Question

Drugs having high first pass metabolism

Q170.2 marksShort Answers

Answer

Glyceryl trinitrate, Propranolol (also Lidocaine, Morphine) — undergo extensive hepatic metabolism on first passage through the liver after oral absorption, substantially reducing oral bioavailability; GTN is therefore given sublingually to bypass this, and propranolol’s oral dose is much higher than its IV dose for the same effect.

  1. 1Pharmacokinetics

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