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Paper I — 2017 February (2010 Scheme) — Q12

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Paper I
2017 February (2010 Scheme) · 40 marks · 120 min

Question

Dipivefrine

Q121 marksShort Answers

Answer

Dipivefrine is a prodrug of adrenaline (dipivalyl ester), used topically in the treatment of open-angle glaucoma. Its lipophilic structure allows better corneal penetration than adrenaline itself; once inside the eye, it is hydrolysed by corneal esterases to release active adrenaline, which reduces intraocular pressure by decreasing aqueous humour production and increasing outflow, while causing fewer local side effects (less conjunctival vasoconstriction/irritation) than direct topical adrenaline.

  1. 1Pharmacokinetics

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