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Paper I — 2024 December (Supplementary) (2019 Scheme) — Qx

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Paper I
2024 December (Supplementary) (2019 Scheme) · 100 marks · 180 min

Question

Select the CORRECT statement regarding protein binding of drugs:

  1. Protein bound drug is not available for action.
  2. Highly plasma protein bound drugs tend to have high volume of distribution.
  3. Highly protein bound drugs are generally long acting.
  4. Basic drugs are generally bound to albumin.
  • a) 1 & 2
  • b) 2 & 3
  • c) 3 & 4
  • d) 1 & 3 Question Numbers (xi) – (xv) are based on case scenarios. Read the statements and mark the answers appropriately. A 35-year-old woman with a history of heavy menstrual periods presents with fatigue and dizziness. Blood tests confirm iron deficiency anemia.
Qx1 marksMCQs

Answer

Correct answer: d) 1 & 3 Question Numbers (xi) – (xv) are based on case scenarios. Read the statements and mark the answers appropriately. A 35-year-old woman with a history of heavy menstrual periods presents with fatigue and dizziness. Blood tests confirm iron deficiency anemia.

Only the free (unbound) fraction of a drug is pharmacologically active — protein-bound drug is temporarily unavailable for action. Since the bound fraction acts as a slow-release reservoir, highly protein-bound drugs are generally longer-acting. Highly protein-bound drugs tend to have a low, not high, volume of distribution (confined largely to the plasma compartment), and basic drugs typically bind alpha-1-acid glycoprotein, not albumin (albumin preferentially binds acidic drugs).

  1. 1Pharmacokinetics

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