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Paper II — 2025 March (Supplementary (SAY)) (2019 Scheme) — Qxviii

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Paper II
2025 March (Supplementary (SAY)) (2019 Scheme) · 100 marks · 180 min

Question

Assertion (A): Azathioprine dose is decreased with Allopurinol. Reason (R): Azathioprine and allopurinol cause bone marrow suppression.

Assertion) Azathioprine dose is decreased with Allopurinol. Reason) Azathioprine and allopurinol cause bone marrow suppression.

  • a) Both A and R are true and R is the correct explanation of A
  • c) A is true but R is false
  • b) Both A and R are true and R is not the correct explanation of A
  • d) A is false but R is true
Qxviii1 marksMCQs (A/R)

Answer

Correct answer: b) Both A and R are true and R is not the correct explanation of A

Both statements are individually true, but R does not correctly explain A. The real reason azathioprine’s dose is reduced with allopurinol is pharmacokinetic: allopurinol inhibits xanthine oxidase, the enzyme that normally breaks down azathioprine’s active thiopurine metabolites, so co-administration raises azathioprine’s active drug levels and myelosuppression risk — a metabolic drug interaction, not simply the fact that both drugs can independently cause bone marrow suppression.

  1. 1Pharmacokinetics

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