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Paper II — 2013 September (Supplementary) (2010 Scheme) — Q9

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Paper II
2013 September (Supplementary) (2010 Scheme) · 40 marks · 120 min

Question

Comment on the drug interaction produced by sulfonylureas and salicylates.

Q91 marksShort Answers

Answer

Salicylates displace sulfonylureas from their plasma protein binding sites, increasing the free (active) fraction of the sulfonylurea. Salicylates also have an intrinsic hypoglycaemic action of their own (at high doses) and can inhibit renal excretion of sulfonylurea metabolites. Together, these effects potentiate the hypoglycaemic action of sulfonylureas, increasing the risk of hypoglycaemia when the two are co-administered.

  1. 1Pharmacokinetics

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