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Paper II — 2024 December (Supplementary) (2019 Scheme) — Qxv

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Paper II
2024 December (Supplementary) (2019 Scheme) · 100 marks · 180 min

Question

The WRONGLY paired drug and its influence on thyroid function is:

  • a) Amiodarone – inhibits synthesis and release of thyroid hormones
  • b) Cholestyramine decreases the absorption of thyroid hormones in the gut
  • c) Rifampicin decreases metabolism of thyroid hormones by inhibiting microsomal enzymes
  • d) Sulfonamides inhibit the coupling reaction Question numbers (xvi) – (xx) consists of statements – Assertion (A) and Reason (R). Answer these questions by selecting the appropriate options given below.
Qxv1 marksMCQs

Answer

Correct answer: c) Rifampicin decreases metabolism of thyroid hormones by inhibiting microsomal enzymes

This pairing is wrong — rifampicin is a potent hepatic enzyme inducer, not an inhibitor. It increases (not decreases) the metabolism of thyroid hormones by inducing microsomal enzymes, accelerating their clearance — this can precipitate hypothyroidism or require an increased levothyroxine dose in patients already on replacement therapy. Amiodarone (iodine-rich, affects synthesis/release), cholestyramine (binds T4 in the gut, reducing enterohepatic reabsorption), and sulfonamides (inhibit the coupling reaction, similar to thioamides) are all correctly paired.

  1. 1Pharmacokinetics

Other Years Asked

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  4. 4Briefly describe drug biotransformation. Describe microsomal enzyme induction. (4+4)2023 July (Supplementary) (2019 Scheme)Short Essay · 8 marks
  5. 5Define bioavailability. What are the factors that affect bioavailability of drugs (1+5)2024 December (Supplementary) (2019 Scheme)Short Essay · 6 marks
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  11. 11Desferrioxamine2018 July (Supplementary) (2010 Scheme)Short Note · 3 marks
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  18. 18Apparent volume of distribution2019 February (2010 Scheme)Short Note · 3 marks
  19. 19First pass metabolism2019 July (Supplementary) (2010 Scheme)Short Note · 3 marks
  20. 20Kinetics of elimination2013 April (2010 Scheme)Short Note · 3 marks
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  26. 26Low dose ritonavir2018 July (Supplementary) (2010 Scheme)Short Answer · 1 mark
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  30. 30Imipenem with cilastatin2021 December (Supplementary) (2010 Scheme)Short Answer · 1 mark
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  39. 39Atracurium2018 February (2010 Scheme)Short Answer · 1 mark
  40. 40Causing peripheral neuritis2018 July (Supplementary) (2010 Scheme)Short Answer · 1 mark
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  42. 42Pro drugs2017 August (Supplementary) (2010 Scheme)Short Answer · 1 mark
  43. 43Chemical antagonism with one example.2014 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
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  47. 47What is a pro drug and mention two examples2013 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
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