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Paper I — 2023 January (Supplementary) (2019 Scheme) — Q17

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Paper I
2023 January (Supplementary) (2019 Scheme) · 100 marks · 180 min

Question

Microsomal enzyme inhibitors

Q170.2 marksShort Answers

Answer

Cimetidine, Ciprofloxacin (also Erythromycin, Ketoconazole) — inhibit hepatic CYP450 enzymes, reducing the metabolism of co-administered drugs and raising their plasma levels, a common source of clinically significant drug interactions.

  1. 1Pharmacokinetics

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  3. 3Briefly describe kinetics of elimination. Add a note on factors modifying drug action. (4+4)2023 January (Supplementary) (2019 Scheme)Short Essay · 8 marks
  4. 4Briefly describe drug biotransformation. Describe microsomal enzyme induction. (4+4)2023 July (Supplementary) (2019 Scheme)Short Essay · 8 marks
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  7. 7Briefly describe enzyme induction and enzyme inhibition with suitable examples.2024 March (Supplementary) (2019 Scheme)Short Answer · 4 marks
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  10. 10First pass metabolism.2016 October (Supplementary) (2010 Scheme)Short Note · 3 marks
  11. 11Desferrioxamine2018 July (Supplementary) (2010 Scheme)Short Note · 3 marks
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  14. 14Define half life of a drug and give its clinical significance2024 August (Supplementary) (2010 Scheme)Short Note · 3 marks
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  18. 18Apparent volume of distribution2019 February (2010 Scheme)Short Note · 3 marks
  19. 19First pass metabolism2019 July (Supplementary) (2010 Scheme)Short Note · 3 marks
  20. 20Kinetics of elimination2013 April (2010 Scheme)Short Note · 3 marks
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  26. 26Low dose ritonavir2018 July (Supplementary) (2010 Scheme)Short Answer · 1 mark
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  40. 40Causing peripheral neuritis2018 July (Supplementary) (2010 Scheme)Short Answer · 1 mark
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  42. 42Pro drugs2017 August (Supplementary) (2010 Scheme)Short Answer · 1 mark
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  47. 47Imipenem and cilastatin2021 February (Supplementary) (2010 Scheme)Short Answer · 1 mark
  48. 48What is a pro drug and mention two examples2013 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  49. 49The drug safe in pregnancy2025 March (Supplementary (SAY)) (2019 Scheme)MCQ (Multi) · 1 mark
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