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Paper I — 2021 December (Supplementary) (2010 Scheme) — Q14

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Paper I
2021 December (Supplementary) (2010 Scheme) · 40 marks · 120 min

Question

Enalapril/amlodipine in hypertension with renal failure

Q140.3 marksShort Answers

Answer

Chosen drug: Amlodipine

Justification: Amlodipine, a calcium channel blocker, does not depend on renal excretion for its major pharmacokinetic clearance and carries no risk of hyperkalaemia or worsening renal function, making it a safer antihypertensive choice in a patient with significant renal impairment. Enalapril, an ACE inhibitor, is cautioned/relatively contraindicated in advanced renal failure — it carries a risk of hyperkalaemia and can precipitate acute deterioration in renal function, particularly in the presence of underlying renal artery disease.

  1. 1Antihypertensives

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