Revise MBBS

Paper I — 2021 May (Supplementary) (2010 Scheme) — Q14

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Paper I
2021 May (Supplementary) (2010 Scheme) · 40 marks · 120 min

Question

Nifedipine / Verapamil in hypertension

Q140.3 marksShort Answers

Answer

Chosen drug: Nifedipine (or another dihydropyridine, e.g., Amlodipine)

Justification: Dihydropyridine calcium channel blockers like nifedipine act predominantly on vascular smooth muscle, producing effective arteriolar vasodilatation with minimal effect on cardiac conduction, making them well suited as routine antihypertensive therapy, especially in elderly patients or those with isolated systolic hypertension. Verapamil, while also lowering blood pressure, has significant negative inotropic and chronotropic effects on the heart and can cause bradycardia/AV block, making it less ideal as a first-line general antihypertensive (though useful when a coexisting arrhythmia needs treatment).

  1. 1Antihypertensives

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