Paper I — 2018 July (Supplementary) (2010 Scheme) — Q8

Paper I

2018 July (Supplementary) (2010 Scheme) · 40 marks · 120 min

Question

Rationale for use of dantrolene sodium in malignant hypertension

Q81 marksShort Answers★✓

Answer

Dantrolene sodium acts directly on skeletal muscle. It binds to the ryanodine receptor (RyR1) on the sarcoplasmic reticulum, inhibiting calcium release into the myoplasm. This reduces excitation-contraction coupling and skeletal muscle rigidity/contraction, which is the specific treatment for malignant hyperthermia (an inherited hypermetabolic reaction to certain anaesthetic agents like halothane/succinylcholine, causing muscle rigidity, hyperthermia, and metabolic acidosis).

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1. 1Antihypertensives

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