Paper I — 2015 September (Supplementary) (2010 Scheme) — Q7

Paper I

2015 September (Supplementary) (2010 Scheme) · 40 marks · 120 min

Question

Ramipril

Q73 marksShort Notes★✓

Answer

Ramipril is an ACE inhibitor.

Mechanism of action

• Inhibits angiotensin-converting enzyme, blocking conversion of angiotensin I to angiotensin II
• Reduces afterload (vasoconstriction) and preload (aldosterone-mediated Na⁺/water retention)
• Prevents bradykinin breakdown, contributing to efficacy and the characteristic dry cough

Uses

• Hypertension
• Congestive cardiac failure (improves survival)
• Post-MI (reduces remodelling)
• Diabetic nephropathy (renoprotective)

Adverse effects

• Dry cough
• Hyperkalaemia
• First-dose hypotension
• Angioedema
• Contraindicated in pregnancy (teratogenic) and bilateral renal artery stenosis

Related Concepts

1. 1Antihypertensives

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