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Paper II — 2022 February (2019 Scheme) — Q10

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Paper II
2022 February (2019 Scheme) · 100 marks · 180 min

Question

Vaccine against Varicella zoster virus.

Q104 marksShort Answers

Answer

Varicella (chickenpox) vaccine: a live attenuated vaccine derived from the Oka strain of Varicella-zoster virus.

Schedule: typically administered as two doses — the first dose around 12–15 months of age, and a second dose at 4–6 years of age (as per most national immunization schedules that include it); can also be given to older children/adults who are non-immune, and as post-exposure prophylaxis if given within 3–5 days of exposure in susceptible individuals.

Purpose/use: prevents primary varicella (chickenpox) infection, and, by reducing the burden of primary infection, reduces the subsequent risk of herpes zoster (shingles) arising from viral reactivation, particularly when administered before natural infection occurs. Contraindicated in pregnancy and in significantly immunocompromised individuals, given its live-attenuated nature.

(A separate, distinct herpes zoster (recombinant subunit) vaccine exists specifically for prevention of shingles/reactivation in older adults, distinct from the primary varicella vaccine.)

  1. 1General Properties of Viruses and Virus Host Interaction

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  4. 4Classify immunity. Add a note on passive immunity.2023 July (Supplementary) (2019 Scheme)Short Essay · 8 marks
  5. 5Explain the reasons that helped successful eradication of smallpox.2022 February (2019 Scheme)Short Essay · 8 marks
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  12. 12Discuss the laboratory diagnosis of hepatitis B virus Infection2014 September (Supplementary) (2010 Scheme)Short Essay · 5 marks
  13. 13Markers of hepatitis B virus and lab. diagnosis of hepatitis B infection.2019 July (Supplementary) (2010 Scheme)Short Essay · 5 marks
  14. 14Active immunity.2017 February (2010 Scheme)Short Essay · 5 marks
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  16. 16Monoclonal antibodies and its application in clinical microbiology2014 September (Supplementary) (2010 Scheme)Short Essay · 5 marks
  17. 17Monoclonal antibodies.2021 December (Supplementary) (2010 Scheme)Short Essay · 5 marks
  18. 18Describe immunoglobulin G (IgG)2017 August (Supplementary) (2010 Scheme)Short Essay · 5 marks
  19. 19Compare and contrast active and passive immunity.2020 February (Supplementary) (2010 Scheme)Short Essay · 5 marks
  20. 20Monoclonal antibody and its application2025 March (Supplementary) (2010 Scheme)Short Essay · 5 marks
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  22. 22Tzanck smear.2022 February (2019 Scheme)Short Answer · 4 marks
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  24. 24PCR – Principle2022 July (Supplementary) (2019 Scheme)Short Answer · 4 marks
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  26. 26Respiratory Syncytial virus.2023 January (Supplementary) (2019 Scheme)Short Answer · 4 marks
  27. 27Write the applications of ELISA test2024 March (Supplementary) (2019 Scheme)Short Answer · 4 marks
  28. 28Modes of transmission and laboratory diagnosis of Monkey pox (M Pox)2024 December (Supplementary) (2019 Scheme)Short Answer · 4 marks
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  30. 30Human papilloma virus and the role of vaccines2025 March (Supplementary (SAY)) (2019 Scheme)Short Answer · 3 marks
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  32. 32Adjuvant.2023 March (Supplementary) (2010 Scheme)Short Note · 2 marks
  33. 33Coxsackie viruses.2013 September (Supplementary) (2010 Scheme)Short Note · 2 marks
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  35. 35Adjuvant2019 July (Supplementary) (2010 Scheme)Short Note · 2 marks
  36. 36Papilloma virus2014 September (Supplementary) (2010 Scheme)Short Note · 2 marks
  37. 37Prions2013 September (Supplementary) (2010 Scheme)Short Note · 2 marks
  38. 38Eclipse phase in viral replication.2014 March (2010 Scheme)Short Note · 2 marks
  39. 39Polio vaccines2024 August (Supplementary) (2010 Scheme)Short Note · 2 marks
  40. 40Monoclonal antibodies and its TWO applications2024 August (Supplementary) (2010 Scheme)Short Note · 2 marks
  41. 41Pulse polio programme.2022 May (Supplementary) (2010 Scheme)Short Note · 2 marks
  42. 42Continuous cell lines2015 February (2010 Scheme)Short Note · 2 marks
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  45. 45Cytopathic effect (CPE)2013 September (Supplementary) (2010 Scheme)Short Note · 2 marks
  46. 46Hepatitis B vaccine2021 December (Supplementary) (2010 Scheme)Short Note · 2 marks
  47. 47Significance of p24 antigen.2014 March (2010 Scheme)Short Note · 2 marks
  48. 48Hereditary angioneurotic edema2015 February (2010 Scheme)Short Note · 2 marks
  49. 49Primary cell culture2021 May (Supplementary) (2010 Scheme)Short Note · 2 marks
  50. 50Natural passive immunity2022 October (Supplementary) (2010 Scheme)Short Note · 2 marks
  51. 51Opportunistic viral infections in AIDS patients.2022 October (Supplementary) (2010 Scheme)Short Note · 2 marks
  52. 52Virus cultivation by cell culture method.2016 October (Supplementary) (2010 Scheme)Short Note · 2 marks
  53. 53Secretory IgA2014 September (Supplementary) (2010 Scheme)Short Note · 2 marks
  54. 54Gamma interferon.2013 September (Supplementary) (2010 Scheme)Short Note · 2 marks
  55. 55Koch’s postulates.2020 February (Supplementary) (2010 Scheme)Short Note · 2 marks
  56. 56Clinical significance of IgM2025 March (Supplementary) (2010 Scheme)Short Note · 2 marks
  57. 57Tissue culture2016 February (2010 Scheme)Short Note · 2 marks
  58. 58Aseptic meningitis2017 February (2010 Scheme)Short Note · 2 marks
  59. 59Adjuvants2016 October (Supplementary) (2010 Scheme)Short Note · 2 marks
  60. 60MMR vaccine.2013 April (2010 Scheme)Short Note · 2 marks
  61. 61IgA2018 February (2010 Scheme)Short Note · 2 marks
  62. 62Elusion2020 February (Supplementary) (2010 Scheme)Short Note · 2 marks
  63. 63Pulse polio programme2020 February (Supplementary) (2010 Scheme)Short Note · 2 marks
  64. 64Gamma interferon.2022 October (Supplementary) (2010 Scheme)Short Note · 2 marks
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  68. 68Window period in HIV infection2021 February (Supplementary) (2010 Scheme)Short Note · 2 marks
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  70. 70Tissue cell line culture2018 July (Supplementary) (2010 Scheme)Short Note · 2 marks
  71. 71Immunofluorescence.2020 February (Supplementary) (2010 Scheme)Short Note · 2 marks
  72. 72Morphology of bacteriophage2013 September (Supplementary) (2010 Scheme)Short Note · 2 marks
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  74. 74Regarding the laboratory diagnosis of HIV infection2025 March (Supplementary (SAY)) (2019 Scheme)MCQ · 1 mark
  75. 75A: B lymphocytes have immunological memory. R: Helper T lymphocytes help B lymphocytes make antibodies2024 December (Supplementary) (2019 Scheme)MCQ · 1 mark
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  77. 77Hand foot and mouth disease is NOT caused by2024 December (Supplementary) (2019 Scheme)MCQ · 1 mark
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  85. 85What is the role of memory cells in immune response.2023 January (Supplementary) (2019 Scheme)1 mark

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