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Paper II — 2024 December (Supplementary) (2019 Scheme) — Qv

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Paper II
2024 December (Supplementary) (2019 Scheme) · 100 marks · 180 min

Question

The protein which acts as virulence factor is the

  • a) Nucleoprotein
  • b) Glycoprotein G
  • c) Matrix protein
  • d) Hemagglutinin Question numbers (vi)-(x) are multiple response type questions. Read the statements & mark the answers appropriately.
Qv1 marksMCQs

Answer

- [x] b) Glycoprotein G

In the context of rabies virus (continuing the theme of the preceding questions in this set), the glycoprotein (G) spike, projecting from the viral envelope, is the principal virulence factor and the primary antigen responsible for host cell receptor attachment, viral entry/pathogenicity, and eliciting the neutralizing antibody response targeted by rabies vaccines. The nucleoprotein and matrix protein are structural components with roles in genome packaging/replication and virion assembly respectively, but are not the principal recognized virulence determinant; haemagglutinin is not a rabies virus protein (it is an influenza virus surface protein), making it an inconsistent option if this question is intended to be rabies-specific — this inconsistency further supports the likelihood of a missing or altered question stem.

  1. 1General Properties of Viruses and Virus Host Interaction

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