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Paper I — 2025 March (Supplementary (SAY)) (2019 Scheme) — Qvi

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Paper I
2025 March (Supplementary (SAY)) (2019 Scheme) · 100 marks · 180 min

Question

Regarding the laboratory diagnosis of HIV infection

  1. P24 antigen detection in window period
  2. NACO strategy III is used in blood banks
  3. RNA detection by PCR is a confirmatory test
  4. Western blot detects antibodies a) 1, 2, 3 are correct b) 1, 3, 4 are correct c) 2, 3, 4 are correct d) 1, 2, 4 are correct
  • a) 1, 2, 3 are correct
  • b) 1, 3, 4 are correct
  • c) 2, 3, 4 are correct
  • d) 1, 2, 4 are correct
Qvi1 marksMCQs

Answer

Key facts regarding the laboratory diagnosis of HIV infection: ELISA (including 4th-generation combined antigen-antibody assays) is used as the initial screening test; a reactive screening result must be confirmed using the NACO three-test strategy (two further different rapid/ELISA kits, using different antigen preparations/test principles), with positivity declared only if reactive on all three; HIV RNA PCR and p24 antigen detection are useful for early diagnosis during the antibody-negative window period; Western blot, though traditionally used as a confirmatory test in some settings, has largely been superseded in India by the sequential three-test rapid/ELISA algorithm; CD4 count is used for disease staging and monitoring, not for diagnosis itself. Without the original four numbered statements from the source question, the specific combination intended by the examiner cannot be confirmed.

  1. 1General Properties of Viruses and Virus Host Interaction

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