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Paper I — 2024 June (Supplementary) (2019 Scheme) — Q19

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Paper I
2024 June (Supplementary) (2019 Scheme) · 100 marks · 180 min

Question

Define acute phase reactants. Give one example.

Q191 marks

Answer

Acute phase reactants: proteins whose plasma concentration changes significantly (increases or decreases) in response to acute inflammation/tissue injury/infection, as part of the innate “acute phase response” driven by pro-inflammatory cytokines (IL-6, IL-1, TNF-α) acting on the liver.

Example: C-reactive protein (CRP) — a positive acute phase reactant, whose serum level rises rapidly (within hours) in response to inflammation/infection, commonly used clinically as a marker of acute inflammation/infection.

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