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Paper I — 2024 December (Supplementary) (2019 Scheme) — Qvii

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Paper I
2024 December (Supplementary) (2019 Scheme) · 100 marks · 180 min

Question

Western blot test for HIV

  1. is a supplemental test
  2. Is a confirmatory test as it detects antigens of HIV
  3. Detects antibodies against HIV
  4. is based on immunoblotting technique a) 1, 2, 3 are correct b) 1, 2, 4 are correct c) 1, 3, 4 are correct d) 2, 3, 4 are correct
  • a) 1, 2, 3 are correct
  • b) 1, 2, 4 are correct
  • c) 1, 3, 4 are correct
  • d) 2, 3, 4 are correct
Qvii1 marksMCQs

Answer

The Western blot test for HIV is a confirmatory serological test, detecting antibody directed against specific individual HIV structural proteins separated by molecular weight — envelope glycoproteins (gp160, gp120, gp41) and core/gag proteins (p24, p17, p55) and polymerase (pol) gene products. A sample is typically classified positive if it shows reactivity to a defined combination of these bands (per WHO/CDC criteria, e.g., reactivity to at least two of gp41, gp120/160, and p24), indeterminate if it shows some but insufficient band reactivity, and negative if no bands are present. It has traditionally been used to confirm a reactive screening ELISA/rapid test result, though many current national testing algorithms (including NACO’s Strategy III) now use a sequence of different ELISA/rapid tests rather than Western blot as the confirmatory step. Without the original four numbered statements from the source question, the specific combination intended by the examiner cannot be confirmed.

  1. 1General Properties of Viruses and Virus Host Interaction

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