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Paper I — 2016 October (Supplementary) (2010 Scheme) — Q8

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Paper I
2016 October (Supplementary) (2010 Scheme) · 40 marks · 120 min

Question

Rationale for the use of glycopyrrolate in pre-anesthetic medication.

Q81 marksShort Answers

Answer

Glycopyrrolate is a quaternary ammonium anticholinergic that does not cross the blood-brain barrier (unlike atropine), so it produces peripheral antimuscarinic effects (reduced salivary/respiratory secretions, prevention of vagally-mediated bradycardia during intubation/surgery) without central nervous system side effects (sedation, confusion). It is also less likely to cause tachycardia than atropine, and has a longer duration of action, making it preferable as a premedication agent.

  1. 1Cholinergic System

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