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Paper I — 2022 October (Supplementary) (2010 Scheme) — Q14

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Paper I
2022 October (Supplementary) (2010 Scheme) · 40 marks · 120 min

Question

Physostigmine/Neostigmine for Atropine poisoning

Q140.3 marksShort Answers

Answer

Physostigmine is the appropriate choice — a tertiary amine anticholinesterase that crosses the blood-brain barrier, reversing the central anticholinergic toxicity (delirium, hallucinations, coma) of atropine poisoning in addition to peripheral effects. Neostigmine, a quaternary compound, cannot cross the BBB and so would reverse only peripheral antimuscarinic effects, leaving the dangerous CNS toxicity untreated.

  1. 1Cholinergic System

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  1. 1(2024 March (Supplementary) (2019 Scheme)Short Essay · 8 marks
  2. 2(2023 July (Supplementary) (2019 Scheme)Short Essay · 8 marks
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  14. 14Pharmacological basis for the use of Timolol in glaucoma.2024 June (Supplementary) (2019 Scheme)Short Answer · 4 marks
  15. 15Pharmacological management of Myasthenia gravis.2022 July (Supplementary) (2019 Scheme)Short Answer · 4 marks
  16. 16Treatment of organophosphorus poisoning2013 September (Supplementary) (2010 Scheme)Short Note · 3 marks
  17. 17Drug treatment of anti cholinesterase poisoning2013 April (2010 Scheme)Short Note · 3 marks
  18. 18Neostigmine2021 December (Supplementary) (2010 Scheme)Short Note · 3 marks
  19. 19Treatment of organophosphorous poisoning2014 September (Supplementary) (2010 Scheme)Short Note · 3 marks
  20. 20Atropine2015 February (2010 Scheme)Short Note · 3 marks
  21. 21Therapeutic uses and adverse effects of atropine.2016 October (Supplementary) (2010 Scheme)Short Note · 3 marks
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  23. 23Edrophonium2018 February (2010 Scheme)Short Note · 3 marks
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  37. 37Rationale for use of physostigmine in atropine poisoning2015 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
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  39. 39Cholinesterase reactivators2015 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
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  42. 42Used in treatment of acute congestive glaucoma2018 February (2010 Scheme)Short Answer · 1 mark
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