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Paper I — 2024 June (Supplementary) (2019 Scheme) — Q10

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Paper I
2024 June (Supplementary) (2019 Scheme) · 100 marks · 180 min

Question

Pharmacological basis for the use of Timolol in glaucoma.

Q104 marksShort Answers

Answer

Aqueous humour is continuously formed by the ciliary epithelium through a beta-adrenergic-receptor-driven, cAMP-mediated secretory process. Timolol, a non-selective beta-blocker, blocks these beta receptors on the ciliary epithelium, reducing cAMP-mediated aqueous humour production and thereby lowering intraocular pressure. Given topically as an eye-drop, systemic absorption is low at ocular doses, though not negligible — systemic contraindications (bronchial asthma, heart block, bradycardia) still apply despite the local route of administration.

  1. 1Cholinergic System

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  1. 1(2024 March (Supplementary) (2019 Scheme)Short Essay · 8 marks
  2. 2(2023 July (Supplementary) (2019 Scheme)Short Essay · 8 marks
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  14. 14Pharmacological management of Myasthenia gravis.2022 July (Supplementary) (2019 Scheme)Short Answer · 4 marks
  15. 15Treatment of organophosphorus poisoning2013 September (Supplementary) (2010 Scheme)Short Note · 3 marks
  16. 16Drug treatment of anti cholinesterase poisoning2013 April (2010 Scheme)Short Note · 3 marks
  17. 17Neostigmine2021 December (Supplementary) (2010 Scheme)Short Note · 3 marks
  18. 18Treatment of organophosphorous poisoning2014 September (Supplementary) (2010 Scheme)Short Note · 3 marks
  19. 19Atropine2015 February (2010 Scheme)Short Note · 3 marks
  20. 20Therapeutic uses and adverse effects of atropine.2016 October (Supplementary) (2010 Scheme)Short Note · 3 marks
  21. 21Neostigmine.2017 August (Supplementary) (2010 Scheme)Short Note · 3 marks
  22. 22Edrophonium2018 February (2010 Scheme)Short Note · 3 marks
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  28. 28Anti- muscarinic drugs2017 August (Supplementary) (2010 Scheme)Short Answer · 1 mark
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  37. 37Rationale for the use of glycopyrrolate in pre-anesthetic medication.2016 October (Supplementary) (2010 Scheme)Short Answer · 1 mark
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  41. 41Used in treatment of acute congestive glaucoma2018 February (2010 Scheme)Short Answer · 1 mark
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