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Paper I — 2017 August (Supplementary) (2010 Scheme) — Q9

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Paper I
2017 August (Supplementary) (2010 Scheme) · 40 marks · 120 min

Question

Explain the rationale for the use of oximes in organophosphorus poisoning.

Q91 marksShort Answers

Answer

Oximes (e.g., Pralidoxime) act as cholinesterase reactivators. Organophosphates phosphorylate and inactivate acetylcholinesterase; oximes have a strong affinity for the phosphorus atom of the OP-enzyme complex and remove it, regenerating active acetylcholinesterase. This reverses both the muscarinic and, importantly, the nicotinic (neuromuscular) effects of OP poisoning — which atropine alone cannot address. Oximes are most effective if given early, before “ageing” (a further chemical change that makes the enzyme-inhibitor bond permanently resistant to reactivation) occurs.

  1. 1Cholinergic System

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