Paper I
2025 March (Supplementary) (2010 Scheme) · 40 marks · 120 min

Question

Trihexyphenidyl /Levodopa in Drug induced parkinsonism. Name the following (Two examples for each): (5x1=5)

Q150.3 marksShort Answers

Answer

Trihexyphenidyl is the appropriate choice — drug-induced parkinsonism results from dopamine D2 receptor blockade (typically by antipsychotics), not dopamine deficiency, so restoring the dopamine-acetylcholine balance by blocking the resulting relative cholinergic excess (a centrally acting antimuscarinic) directly addresses the mechanism. Levodopa would be ineffective, since the problem is blocked receptors, not insufficient dopamine synthesis, and could also antagonize the therapeutic action of the causative antipsychotic.

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