Paper II
2014 September (Supplementary) (2010 Scheme) · 40 marks · 120 min

Question

Rationale of estrogen in hormone replacement therapy

Q121 marksShort Answers

Answer

Oestrogen is given in hormone replacement therapy to relieve the symptoms of oestrogen deficiency following menopause — vasomotor symptoms (hot flushes, night sweats), urogenital atrophy, and to prevent postmenopausal osteoporosis (oestrogen inhibits osteoclastic bone resorption). It is combined with a progestin in women with an intact uterus to prevent oestrogen-induced endometrial hyperplasia/carcinoma (unopposed oestrogen risk).

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