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Paper II — 2024 December (Supplementary) (2019 Scheme) — Q12

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Paper II
2024 December (Supplementary) (2019 Scheme) · 100 marks · 180 min

Question

Mention two anabolic steroids. Enumerate the uses and adverse effects of anabolic steroids.

Q124 marksShort Answers

Answer

Two anabolic steroids: Nandrolone, Stanozolol.

Uses: cachexia/wasting states (chronic illness), hereditary angioedema (Danazol), hypogonadism (testosterone replacement), historically for aplastic anemia (largely superseded now). Misused for athletic performance/muscle mass enhancement, an indication with no medical justification.

Adverse effects: virilization in women (hirsutism, voice deepening, menstrual irregularity), hepatotoxicity (particularly with oral 17-alpha-alkylated compounds — cholestatic jaundice, peliosis hepatis, hepatic tumours with long-term use), adverse lipid profile (reduced HDL), premature epiphyseal closure/growth suppression in adolescents, psychiatric effects (aggression, mood disturbance), and suppression of endogenous testosterone/gonadotropin production (testicular atrophy, infertility in men).

  1. 1Gonadal Hormones and Related Drugs

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