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Paper II — 2021 May (Supplementary) (2010 Scheme) — Q9

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Paper II
2021 May (Supplementary) (2010 Scheme)

Question

Letrozole in breast cancer after surgery

Q91 marksShort Answers

Answer

Letrozole is an aromatase inhibitor. In postmenopausal women, peripheral aromatization of androgens (in adipose tissue) becomes the major source of oestrogen after ovarian function ceases. Many breast cancers are hormone-receptor-positive and dependent on oestrogen for growth. By inhibiting aromatase, letrozole blocks this peripheral oestrogen synthesis, depriving residual/micrometastatic tumour cells of the oestrogen needed for growth, making it effective adjuvant (post-surgical) therapy to reduce recurrence risk in hormone-receptor-positive early breast cancer in postmenopausal women.

  1. 1Gonadal Hormones and Related Drugs

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  5. 5(2023 January (Supplementary) (2019 Scheme)Short Answer · 4 marks
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  10. 10Briefly describe combined Oral Contraceptive Pills. Add a note on emergency contraception. (3+1)2022 July (Supplementary) (2019 Scheme)Short Answer · 4 marks
  11. 11Serious adverse effects produced by oral contraceptive pills2014 March (2010 Scheme)Short Note · 3 marks
  12. 12Raloxifene2018 February (2010 Scheme)Short Note · 3 marks
  13. 13Post coital contraceptives2016 October (Supplementary) (2010 Scheme)Short Note · 3 marks
  14. 14Mifepristone2013 April (2010 Scheme)Short Note · 3 marks
  15. 15Clomiphene citrate.2015 September (Supplementary) (2010 Scheme)Short Note · 3 marks
  16. 16Clomiphene citrate.2025 March (Supplementary) (2010 Scheme)Short Note · 3 marks
  17. 17Clomiphene citrate2017 August (Supplementary) (2010 Scheme)Short Note · 3 marks
  18. 18Mifepristone in termination of pregnancy2022 October (Supplementary) (2010 Scheme)Short Answer · 1 mark
  19. 19Raloxifene2019 February (2010 Scheme)Short Answer · 1 mark
  20. 20Letrozole in early breast cancer2019 July (Supplementary) (2010 Scheme)Short Answer · 1 mark
  21. 21Selective estrogen receptor modulators2015 February (2010 Scheme)Short Answer · 1 mark
  22. 22Tocolytics2014 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  23. 23Selective estrogen receptor modulators2014 March (2010 Scheme)Short Answer · 1 mark
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  25. 25Uterine relaxants2018 July (Supplementary) (2010 Scheme)Short Answer · 1 mark
  26. 26Rationale of estrogen in hormone replacement therapy2014 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  27. 27Treatment of Female Infertility.2017 February (2010 Scheme)Short Answer · 1 mark
  28. 28Clomiphene citrate.2024 March (Supplementary) (2010 Scheme)Short Answer · 1 mark
  29. 29Uterine relaxants2013 April (2010 Scheme)Short Answer · 1 mark
  30. 30Two uses and two adverse effects of oral contraceptive pills2014 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  31. 31Uterine stimulants2013 April (2010 Scheme)Short Answer · 1 mark
  32. 32Uterine stimulants2016 February (2010 Scheme)Short Answer · 1 mark
  33. 33Centchroman2016 February (2010 Scheme)Short Answer · 1 mark
  34. 34Ovulation inhibitors2018 February (2010 Scheme)Short Answer · 1 mark
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  36. 36Anabolic steroids2017 August (Supplementary) (2010 Scheme)Short Answer · 1 mark
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  49. 49Drugs for Emergency contraception2024 June (Supplementary) (2019 Scheme)Short Answer · 0.2 marks
  50. 50Anabolic steroids2024 June (Supplementary) (2019 Scheme)Short Answer · 0.2 marks

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