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Paper II — 2022 October (Supplementary) (2010 Scheme) — Q8

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Paper II
2022 October (Supplementary) (2010 Scheme)

Question

Mifepristone in termination of pregnancy

Q81 marksShort Answers

Answer

Mifepristone is a competitive antagonist at progesterone receptors. Since progesterone is essential for maintaining the decidua and pregnancy, blocking its receptor causes decidual breakdown, detachment of the trophoblast, cervical softening, and increased myometrial sensitivity to prostaglandins — priming the uterus for expulsion. It is combined with misoprostol (a prostaglandin analogue), given after mifepristone, which then triggers effective uterine contractions against this primed, sensitized uterus — the two-drug regimen being substantially more effective than either drug alone for medical termination of pregnancy.

  1. 1Gonadal Hormones and Related Drugs

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