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Paper II — 2025 March (Supplementary (SAY)) (2019 Scheme) — Q10

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Paper II
2025 March (Supplementary (SAY)) (2019 Scheme) · 100 marks · 180 min

Question

Enumerate SERMs. Write in detail about any one member. (2+4)

Q104 marksShort Answers

Answer

SERMs: Tamoxifen, Raloxifene, Clomiphene.

One member in detail — Tamoxifen A selective estrogen receptor modulator, acting as an estrogen antagonist in breast tissue while behaving as a partial agonist in the endometrium and bone. Mechanism: competitively binds estrogen receptors, blocking estrogen-driven proliferative signaling specifically in breast tissue. Uses: ER-positive breast cancer (adjuvant and metastatic therapy), chemoprevention in high-risk women. Adverse effects: hot flushes, increased risk of endometrial hyperplasia/cancer (from its partial agonist action on the endometrium), venous thromboembolism, and an increased risk of cataracts with long-term use. Its bone-agonist action incidentally helps preserve bone mineral density, an added benefit distinct from its anti-tumour action.

  1. 1Gonadal Hormones and Related Drugs

Other Years Asked

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  3. 3A recently married woman comes to your clinic with complaints of calf tenderness. She says she has been using a tablet for preventing pregnancy.2020 February (Supplementary) (2010 Scheme)Essay · 4 marks
  4. 4(2023 January (Supplementary) (2019 Scheme)Short Answer · 4 marks
  5. 5Uses of Selective Estrogen Receptor Modulators2022 July (Supplementary) (2019 Scheme)Short Answer · 4 marks
  6. 6Pharmacological basis for the use of Tamoxifen in Carcinoma Breast.2023 July (Supplementary) (2019 Scheme)Short Answer · 4 marks
  7. 7Classify the Selective Estrogen Receptor Modulators (SERMs) and explain the pharmacological basis of their clinical indications.2024 March (Supplementary) (2019 Scheme)Short Answer · 4 marks
  8. 8Mention two anabolic steroids. Enumerate the uses and adverse effects of anabolic steroids.2024 December (Supplementary) (2019 Scheme)Short Answer · 4 marks
  9. 9Briefly describe combined Oral Contraceptive Pills. Add a note on emergency contraception. (3+1)2022 July (Supplementary) (2019 Scheme)Short Answer · 4 marks
  10. 10Serious adverse effects produced by oral contraceptive pills2014 March (2010 Scheme)Short Note · 3 marks
  11. 11Raloxifene2018 February (2010 Scheme)Short Note · 3 marks
  12. 12Post coital contraceptives2016 October (Supplementary) (2010 Scheme)Short Note · 3 marks
  13. 13Mifepristone2013 April (2010 Scheme)Short Note · 3 marks
  14. 14Clomiphene citrate.2015 September (Supplementary) (2010 Scheme)Short Note · 3 marks
  15. 15Clomiphene citrate.2025 March (Supplementary) (2010 Scheme)Short Note · 3 marks
  16. 16Clomiphene citrate2017 August (Supplementary) (2010 Scheme)Short Note · 3 marks
  17. 17Mifepristone in termination of pregnancy2022 October (Supplementary) (2010 Scheme)Short Answer · 1 mark
  18. 18Raloxifene2019 February (2010 Scheme)Short Answer · 1 mark
  19. 19Letrozole in early breast cancer2019 July (Supplementary) (2010 Scheme)Short Answer · 1 mark
  20. 20Selective estrogen receptor modulators2015 February (2010 Scheme)Short Answer · 1 mark
  21. 21Letrozole in breast cancer after surgery2021 May (Supplementary) (2010 Scheme)Short Answer · 1 mark
  22. 22Tocolytics2014 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  23. 23Selective estrogen receptor modulators2014 March (2010 Scheme)Short Answer · 1 mark
  24. 24Assertion (A): Sildenafil is used in male sexual dysfunction. Reason (R): Sildenafil is a phosphodiesterase inhibitor causes accumulation of cGMP and marked potentiation of actions of nitric oxide.2024 December (Supplementary) (2019 Scheme)MCQ · 1 mark
  25. 25Uterine relaxants2018 July (Supplementary) (2010 Scheme)Short Answer · 1 mark
  26. 26Rationale of estrogen in hormone replacement therapy2014 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  27. 27Treatment of Female Infertility.2017 February (2010 Scheme)Short Answer · 1 mark
  28. 28Clomiphene citrate.2024 March (Supplementary) (2010 Scheme)Short Answer · 1 mark
  29. 29Uterine relaxants2013 April (2010 Scheme)Short Answer · 1 mark
  30. 30Two uses and two adverse effects of oral contraceptive pills2014 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  31. 31Uterine stimulants2013 April (2010 Scheme)Short Answer · 1 mark
  32. 32Uterine stimulants2016 February (2010 Scheme)Short Answer · 1 mark
  33. 33Centchroman2016 February (2010 Scheme)Short Answer · 1 mark
  34. 34Ovulation inhibitors2018 February (2010 Scheme)Short Answer · 1 mark
  35. 35Combination of Oestrogen and Progesterone in Oral contraceptive pills2025 March (Supplementary) (2010 Scheme)Short Answer · 1 mark
  36. 36Anabolic steroids2017 August (Supplementary) (2010 Scheme)Short Answer · 1 mark
  37. 37Raloxifene is used in the treatment of Osteoporosis in postmenopausal women2025 August (Supplementary) (2010 Scheme)Short Answer · 1 mark
  38. 38Rationale for the combination of oestrogen and progesterone in OCPs.2013 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  39. 39Selective Estrogen Receptor Modulators.2025 March (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  40. 40Selective Estrogen Receptor Modulators (SERM)2024 August (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  41. 41Topical steroids2021 May (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  42. 42Mini pill as oral contraception Name the following (Two examples for each) (5x1=5)2022 May (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  43. 43Selective estrogen receptor modulators2022 May (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  44. 44Antiestrogens2021 February (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  45. 45Anabolic steroids2022 October (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  46. 46Anti-progestins2022 February (2019 Scheme)Short Answer · 0.2 marks
  47. 47Anabolic steroids.2022 July (Supplementary) (2019 Scheme)Short Answer · 0.2 marks
  48. 48Antioestrogens.2023 July (Supplementary) (2019 Scheme)Short Answer · 0.2 marks
  49. 49Drugs for Emergency contraception2024 June (Supplementary) (2019 Scheme)Short Answer · 0.2 marks
  50. 50Anabolic steroids2024 June (Supplementary) (2019 Scheme)Short Answer · 0.2 marks

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