Paper II
2024 December (Supplementary) (2019 Scheme) · 100 marks · 180 min

Question

Assertion (A): Sildenafil is used in male sexual dysfunction. Reason (R): Sildenafil is a phosphodiesterase inhibitor causes accumulation of cGMP and marked potentiation of actions of nitric oxide.

  • a) Both A and R are true, and R is the correct explanation of A
  • c) A is true, but R is false
  • b) Both A and R are true, and R is not the correct explanation of A
  • d) A is false, but R is true
Qxvii1 marksMCQs

Answer

Correct answer: a) Both A and R are true, and R is the correct explanation of A

Both statements are true, and R correctly explains A: sildenafil inhibits phosphodiesterase type 5, preventing breakdown of cGMP; the resulting cGMP accumulation potentiates nitric oxide-mediated smooth muscle relaxation in the corpus cavernosum, enhancing penile blood flow and erection — the direct mechanistic basis for its use in erectile dysfunction.

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