Revise MBBS

Paper II — 2023 July (Supplementary) (2019 Scheme) — Q8

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Paper II
2023 July (Supplementary) (2019 Scheme) · 100 marks · 180 min

Question

Pharmacological basis for the use of Tamoxifen in Carcinoma Breast.

Q84 marksShort Answers

Answer

Tamoxifen is a selective estrogen receptor modulator used in ER-positive breast cancer. It competitively binds estrogen receptors in breast tissue, acting as an antagonist there and blocking estrogen-driven proliferative signaling that would otherwise promote growth of ER-positive tumour cells — the direct rationale for its use as adjuvant and metastatic therapy in this specific tumour subtype. It is used only where the tumour is confirmed ER-positive, since its antagonist action is specifically tissue-selective and would offer no benefit in ER-negative disease. Its partial agonist action in the endometrium (raising endometrial cancer risk) and bone is a separate, tissue-specific consequence of the same tissue-selective mechanism, not relevant to its anti-tumour rationale in the breast itself.

  1. 1Gonadal Hormones and Related Drugs

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  5. 5(2023 January (Supplementary) (2019 Scheme)Short Answer · 4 marks
  6. 6Uses of Selective Estrogen Receptor Modulators2022 July (Supplementary) (2019 Scheme)Short Answer · 4 marks
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  8. 8Mention two anabolic steroids. Enumerate the uses and adverse effects of anabolic steroids.2024 December (Supplementary) (2019 Scheme)Short Answer · 4 marks
  9. 9Briefly describe combined Oral Contraceptive Pills. Add a note on emergency contraception. (3+1)2022 July (Supplementary) (2019 Scheme)Short Answer · 4 marks
  10. 10Serious adverse effects produced by oral contraceptive pills2014 March (2010 Scheme)Short Note · 3 marks
  11. 11Raloxifene2018 February (2010 Scheme)Short Note · 3 marks
  12. 12Post coital contraceptives2016 October (Supplementary) (2010 Scheme)Short Note · 3 marks
  13. 13Mifepristone2013 April (2010 Scheme)Short Note · 3 marks
  14. 14Clomiphene citrate.2015 September (Supplementary) (2010 Scheme)Short Note · 3 marks
  15. 15Clomiphene citrate.2025 March (Supplementary) (2010 Scheme)Short Note · 3 marks
  16. 16Clomiphene citrate2017 August (Supplementary) (2010 Scheme)Short Note · 3 marks
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  18. 18Raloxifene2019 February (2010 Scheme)Short Answer · 1 mark
  19. 19Letrozole in early breast cancer2019 July (Supplementary) (2010 Scheme)Short Answer · 1 mark
  20. 20Selective estrogen receptor modulators2015 February (2010 Scheme)Short Answer · 1 mark
  21. 21Letrozole in breast cancer after surgery2021 May (Supplementary) (2010 Scheme)Short Answer · 1 mark
  22. 22Tocolytics2014 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  23. 23Selective estrogen receptor modulators2014 March (2010 Scheme)Short Answer · 1 mark
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  25. 25Uterine relaxants2018 July (Supplementary) (2010 Scheme)Short Answer · 1 mark
  26. 26Rationale of estrogen in hormone replacement therapy2014 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  27. 27Treatment of Female Infertility.2017 February (2010 Scheme)Short Answer · 1 mark
  28. 28Clomiphene citrate.2024 March (Supplementary) (2010 Scheme)Short Answer · 1 mark
  29. 29Uterine relaxants2013 April (2010 Scheme)Short Answer · 1 mark
  30. 30Two uses and two adverse effects of oral contraceptive pills2014 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  31. 31Uterine stimulants2013 April (2010 Scheme)Short Answer · 1 mark
  32. 32Uterine stimulants2016 February (2010 Scheme)Short Answer · 1 mark
  33. 33Centchroman2016 February (2010 Scheme)Short Answer · 1 mark
  34. 34Ovulation inhibitors2018 February (2010 Scheme)Short Answer · 1 mark
  35. 35Combination of Oestrogen and Progesterone in Oral contraceptive pills2025 March (Supplementary) (2010 Scheme)Short Answer · 1 mark
  36. 36Anabolic steroids2017 August (Supplementary) (2010 Scheme)Short Answer · 1 mark
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  40. 40Selective Estrogen Receptor Modulators (SERM)2024 August (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  41. 41Topical steroids2021 May (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
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  44. 44Antiestrogens2021 February (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  45. 45Anabolic steroids2022 October (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  46. 46Anti-progestins2022 February (2019 Scheme)Short Answer · 0.2 marks
  47. 47Anabolic steroids.2022 July (Supplementary) (2019 Scheme)Short Answer · 0.2 marks
  48. 48Antioestrogens.2023 July (Supplementary) (2019 Scheme)Short Answer · 0.2 marks
  49. 49Drugs for Emergency contraception2024 June (Supplementary) (2019 Scheme)Short Answer · 0.2 marks
  50. 50Anabolic steroids2024 June (Supplementary) (2019 Scheme)Short Answer · 0.2 marks

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