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Paper II — 2025 March (Supplementary (SAY)) (2019 Scheme) — Qii

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Paper II
2025 March (Supplementary (SAY)) (2019 Scheme) · 100 marks · 180 min

Question

The anticancer drug which acts by inhibiting Topoisomerase II, thereby causing DNA strand breaks is:

  • a) Methotrexate
  • b) Doxorubicin
  • c) Vinblastine
  • d) 5-Fluorouracil
Qii1 marksMCQs

Answer

Correct answer: b) Doxorubicin

Doxorubicin (an anthracycline antitumour antibiotic) intercalates into DNA and inhibits topoisomerase II, preventing the resealing of DNA strand breaks the enzyme normally creates and repairs during replication — the accumulated unrepaired strand breaks are cytotoxic. Methotrexate (folate antagonist), vinblastine (mitotic spindle inhibitor), and 5-fluorouracil (pyrimidine antagonist) act through entirely different mechanisms.

  1. 1Cancer Chemotherapy

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