Paper II — 2024 March (Supplementary) (2010 Scheme) — Q20

Paper II

2024 March (Supplementary) (2010 Scheme)

Question

Vinca alkaloids.

Q200.3 marksShort Answers★✓

Answer

Vincristine, Vinblastine — bind tubulin and inhibit microtubule polymerization, arresting cells in metaphase (mitotic spindle inhibitors); vincristine causes prominent peripheral neuropathy with comparatively little myelosuppression, while vinblastine causes more myelosuppression with less neurotoxicity.

Related Concepts

1. 1Cancer Chemotherapy

Other Years Asked

1. 1Mechanism of action, therapeutic uses and adverse effects of vinca alkaloids.2025 March (Supplementary (SAY)) (2019 Scheme)Short Essay · 6 marks
2. 2Alkylating agents and their uses in cancer chemotherapy2024 March (Supplementary) (2019 Scheme)Short Answer · 4 marks
3. 3Vinca alkaloids2024 June (Supplementary) (2019 Scheme)Short Answer · 4 marks
4. 4Cyclophosphamide.2022 July (Supplementary) (2019 Scheme)Short Answer · 4 marks
5. 5Methotrexate2022 February (2019 Scheme)Short Answer · 4 marks
6. 6Methotrexate2016 October (Supplementary) (2010 Scheme)Short Note · 3 marks
7. 7Taxanes in cancer chemotherapy.2014 September (Supplementary) (2010 Scheme)Short Note · 3 marks
8. 8Cyclophosphamide2021 February (Supplementary) (2010 Scheme)Short Note · 3 marks
9. 9Methotrexate2024 March (Supplementary) (2010 Scheme)Short Note · 3 marks
10. 10Vinca alkaloids2023 March (Supplementary) (2010 Scheme)Short Note · 3 marks
11. 11Vinca alkaloids2014 March (2010 Scheme)Short Note · 3 marks
12. 12Vinca Alkaloids2024 August (Supplementary) (2010 Scheme)Short Note · 3 marks
13. 13Methotrexate2019 February (2010 Scheme)Short Note · 3 marks
14. 14Antibiotics used in cancer chemotherapy2021 May (Supplementary) (2010 Scheme)Short Note · 3 marks
15. 15Methotrexate.2017 February (2010 Scheme)Short Note · 3 marks
16. 16Alkylating agents2022 May (Supplementary) (2010 Scheme)Short Note · 3 marks
17. 17Methotrexate2016 February (2010 Scheme)Short Note · 3 marks
18. 18Cyclophosphamide2013 April (2010 Scheme)Short Note · 3 marks
19. 19Vinca alkaloids2020 February (Supplementary) (2010 Scheme)Short Note · 3 marks
20. 20Methotrexate2025 August (Supplementary) (2010 Scheme)Short Note · 3 marks
21. 21MESNA is administered during cyclophosphamide therapy2023 July (Supplementary) (2010 Scheme)Short Answer · 1 mark
22. 22Rationale for the use of combination of drugs in cancer chemotherapy2017 August (Supplementary) (2010 Scheme)Short Answer · 1 mark
23. 23Two uses of methotrexate2018 July (Supplementary) (2010 Scheme)Short Answer · 1 mark
24. 24Methotrexate.2025 March (Supplementary) (2010 Scheme)Short Answer · 1 mark
25. 25Antitumor antibiotics2018 February (2010 Scheme)Short Answer · 1 mark
26. 26The anticancer drug which acts by inhibiting Topoisomerase II, thereby causing DNA strand breaks is:2025 March (Supplementary (SAY)) (2019 Scheme)MCQ · 1 mark
27. 27Aromatase inhibitors2014 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
28. 28Folinic acid along with 5 – fluorouracil2021 May (Supplementary) (2010 Scheme)Short Answer · 1 mark
29. 29Rationale for the use of folinic acid in methotrexate toxicity.2015 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
30. 30Rationale for the use of folinic acid in methotrexate overdose2017 August (Supplementary) (2010 Scheme)Short Answer · 1 mark
31. 31Anti tumor antibiotics2016 February (2010 Scheme)Short Answer · 1 mark
32. 32Desferrioxamine in Iron poisoning2021 February (Supplementary) (2010 Scheme)Short Answer · 1 mark
33. 33Pharmacological basis for the combined use of drugs in cancer chemotherapy.2015 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
34. 34Why mesna is given simultaneously with cyclophosphamide.2018 February (2010 Scheme)Short Answer · 1 mark
35. 35Cell cycle specific anti metabolites2015 February (2010 Scheme)Short Answer · 1 mark
36. 36Monoclonal antibodies2016 February (2010 Scheme)Short Answer · 1 mark
37. 37 Folinic acid to treat Methotrexate toxicity Name the following (Two examples for each) (5x1=5)2024 August (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
38. 38folic acid in Methotrexate toxicity2023 July (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
39. 39Folinic acid with methotrexate Name the following (Two examples for each) (5x1=5)2021 February (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
40. 40Vinca alkaloids in cancer chemotherapy2019 February (2010 Scheme)Short Answer · 0.3 marks
41. 41Metoclopramide in cancer chemotherapy associated vomiting2021 May (Supplementary) (2010 Scheme)Short Answer · 0.3 marks