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Paper II — 2022 February (2019 Scheme) — Q10

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Paper II
2022 February (2019 Scheme) · 100 marks · 180 min

Question

Methotrexate

Q104 marksShort Answers

Answer

Methotrexate is a folate-antagonist antimetabolite. MOA: competitively inhibits dihydrofolate reductase, blocking tetrahydrofolate regeneration and halting purine/thymidine synthesis, arresting DNA replication (S-phase specific). Leucovorin (folinic acid) rescue allows higher doses while sparing normal host cells. Uses: acute lymphoblastic leukemia, lymphomas, choriocarcinoma; at low doses — rheumatoid arthritis, psoriasis (immunomodulatory). Adverse effects: bone marrow suppression, mucositis, hepatotoxicity, nephrotoxicity, teratogenicity.

  1. 1Cancer Chemotherapy

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