Paper II — 2025 March (Supplementary (SAY)) (2019 Scheme) — Q8

Paper II

2025 March (Supplementary (SAY)) (2019 Scheme) · 100 marks · 180 min

Question

Mechanism of action, therapeutic uses and adverse effects of vinca alkaloids.

Q86 marksShort Essays★✓

Answer

Vinca alkaloids are mitotic spindle inhibitors, cell-cycle-specific (M-phase).

Mechanism of action: bind tubulin, inhibiting microtubule polymerization and preventing mitotic spindle formation — arresting cells in metaphase.

Examples: Vincristine, Vinblastine.

Therapeutic uses: leukemias, lymphomas (vincristine, part of standard combination regimens such as CHOP), solid tumors (vinblastine — testicular cancer, Hodgkin lymphoma).

Adverse effects: vincristine — peripheral neuropathy (dose-limiting, with comparatively little myelosuppression); vinblastine — more prominent myelosuppression, less neurotoxicity. Both are vesicants if extravasated, and can cause constipation/paralytic ileus from autonomic neuropathy.

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