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Paper II — 2024 June (Supplementary) (2019 Scheme) — Q10

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Paper II
2024 June (Supplementary) (2019 Scheme) · 100 marks · 180 min

Question

Vinca alkaloids

Q104 marksShort Answers

Answer

Vinca alkaloids are mitotic spindle inhibitors, cell-cycle-specific (M-phase).

Examples: Vincristine, Vinblastine.

MOA: bind tubulin, inhibiting microtubule polymerization and preventing mitotic spindle formation — arresting cells in metaphase.

Uses: leukemias, lymphomas (vincristine, part of standard combination regimens), solid tumors (vinblastine — testicular cancer, Hodgkin lymphoma).

Adverse effects: vincristine — peripheral neuropathy (dose-limiting); vinblastine — more prominent myelosuppression. Both are vesicants if extravasated.

  1. 1Cancer Chemotherapy

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