Paper II — 2020 February (Supplementary) (2010 Scheme) — Q7

Paper II

2020 February (Supplementary) (2010 Scheme)

Question

Vinca alkaloids

Q73 marksShort Notes★✓

Answer

Vinca alkaloids are plant-derived anticancer drugs.

Examples

• Vincristine, Vinblastine, Vinorelbine

Mechanism of action

• Bind to tubulin, inhibiting microtubule polymerization, preventing mitotic spindle formation, arresting cells in metaphase (M-phase specific)

Uses

• Vincristine: ALL, lymphomas (combination regimens)
• Vinblastine: Hodgkin’s lymphoma, testicular cancer

Adverse effects

• Vincristine: peripheral neuropathy (dose-limiting), constipation
• Vinblastine: myelosuppression (more than vincristine)
• Both: alopecia; vesicant on extravasation

Related Concepts

1. 1Cancer Chemotherapy

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