Paper II — 2021 February (Supplementary) (2010 Scheme) — Q8

Paper II

2021 February (Supplementary) (2010 Scheme)

Question

Desferrioxamine in Iron poisoning

Q81 marksShort Answers★✓

Answer

Desferrioxamine is an iron-chelating agent. In iron poisoning, it binds free (non-transferrin-bound) circulating iron with high affinity, forming a water-soluble complex (ferrioxamine) that is excreted in urine, thereby reducing the toxic free iron burden responsible for GI corrosion, hepatotoxicity, and cardiovascular collapse in acute iron overdose — making it the specific antidote for iron poisoning.

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