Paper II — 2021 May (Supplementary) (2010 Scheme) — Q14

Paper II

2021 May (Supplementary) (2010 Scheme)

Question

Ondanesetron/Metoclopramide in cancer chemotherapy associated vomiting

Q140.3 marksShort Answers★✓

Answer

Chosen drug: Ondansetron

Justification: Ondansetron, a selective 5-HT3 receptor antagonist, is highly effective and specifically targets the serotonin-mediated pathway that predominates in chemotherapy-induced nausea and vomiting (both acute and, combined with other agents, delayed phases), with a favourable safety profile including minimal extrapyramidal risk. Metoclopramide, a D2 antagonist, is less effective for highly emetogenic chemotherapy and carries a higher risk of extrapyramidal side effects (especially at the high doses sometimes needed for chemotherapy-induced vomiting), making ondansetron the preferred choice.

Related Concepts

1. 1Cancer Chemotherapy

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