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Paper II — 2024 August (Supplementary) (2010 Scheme) — Q6

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Paper II
2024 August (Supplementary) (2010 Scheme)

Question

Vinca Alkaloids

Q63 marksShort Notes

Answer

Vinca alkaloids are mitotic spindle inhibitors, cell-cycle-specific (M-phase).

Examples: Vincristine, Vinblastine.

MOA: vinca alkaloid → binds tubulin → inhibits microtubule polymerization → prevents mitotic spindle formation → arrests cells in metaphase.

Uses: leukemias, lymphomas (vincristine, part of standard combination regimens such as CHOP), solid tumors (vinblastine — testicular cancer, Hodgkin lymphoma).

Adverse effects: vincristine — peripheral neuropathy (dose-limiting, with comparatively little myelosuppression); vinblastine — more prominent myelosuppression, less neurotoxicity. Both are vesicants if extravasated.

  1. 1Cancer Chemotherapy

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