Paper II — 2023 July (Supplementary) (2010 Scheme) — Q10

Paper II

2023 July (Supplementary) (2010 Scheme)

Question

MESNA is administered during cyclophosphamide therapy

Q101 marksShort Answers★✓

Answer

Cyclophosphamide’s hepatic activation to its active alkylating metabolites also generates acrolein as a toxic byproduct, which is excreted in the urine and causes hemorrhagic cystitis by damaging the bladder mucosa. Mesna is a thiol compound that binds and neutralizes acrolein directly within the urinary tract, preventing this bladder toxicity without interfering with cyclophosphamide’s own antitumor alkylating action elsewhere in the body — a targeted, antidote-like co-therapy rather than a generic supportive measure.

Related Concepts

1. 1Cancer Chemotherapy

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