Paper II — 2024 August (Supplementary) (2010 Scheme) — Q4

Paper II

2024 August (Supplementary) (2010 Scheme)

Question

Ondansetron

Q43 marksShort Notes★✓

Answer

Ondansetron is a 5-HT3 receptor antagonist.

MOA: ondansetron → blocks serotonin (5-HT3) receptors both peripherally (vagal afferents, relevant to enterochromaffin-cell serotonin release from chemotherapy/radiation mucosal damage) and centrally at the chemoreceptor trigger zone.

Uses: chemotherapy-induced nausea and vomiting (first-line, combining peripheral and central blockade), postoperative nausea/vomiting, radiotherapy-induced emesis.

Adverse effects: headache and constipation (5-HT3 receptors also mediate normal GI motility), QT prolongation (a class-wide caution, requiring care with other QT-prolonging drugs and in patients with cardiac risk factors).

Related Concepts

1. 1Antiemetics

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