Paper II — 2022 October (Supplementary) (2010 Scheme) — Q14

Paper II

2022 October (Supplementary) (2010 Scheme)

Question

Ondansetron/Domperidone in chemotherapy induced vomiting.

Q140.3 marksShort Answers★✓

Answer

Ondansetron is the appropriate choice — a 5-HT3 receptor antagonist blocking serotonin’s action both peripherally (vagal afferents, relevant to chemotherapy-induced enterochromaffin-cell serotonin release) and centrally at the chemoreceptor trigger zone, addressing both mechanisms simultaneously involved in chemotherapy-induced nausea and vomiting (CINV), making it first-line for this specific indication. Domperidone, a D2 antagonist, is a weaker antiemetic for CINV specifically, since it does not address the serotonin-mediated component that dominates the acute phase of chemotherapy-induced emesis.

Related Concepts

1. 1Antiemetics

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