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Paper II — 2021 February (Supplementary) (2010 Scheme) — Q6

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Paper II
2021 February (Supplementary) (2010 Scheme)

Question

Metoclopramide

Q63 marksShort Notes

Answer

Metoclopramide is a dopamine D2 receptor antagonist with antiemetic and prokinetic properties.

Mechanism of action

  • Centrally: blocks D2 receptors in the chemoreceptor trigger zone (antiemetic effect)
  • Peripherally: enhances acetylcholine release, increasing gastric/upper GI motility, LES tone, and gastric emptying (prokinetic)

Uses

  • Nausea and vomiting (chemotherapy, postoperative, GI-related)
  • GERD, gastroparesis
  • Diagnostic aid (facilitating small bowel intubation/radiological studies)

Adverse effects

  • Extrapyramidal symptoms (dystonia, akathisia, especially in children/young adults)
  • Hyperprolactinaemia
  • Sedation, diarrhoea
  1. 1Antiemetics

Other Years Asked

  1. 1Enumerate Antiemetic drugs. Explain the Mechanism of action, uses and adverse effect of any one group. Briefly describe proton pump inhibitors (6+4+5)2024 June (Supplementary) (2019 Scheme)Essay · 15 marks
  2. 2List three classes of Antiemetics. Write the mechanism of action, uses and adverse effects of the most effective Antiemetic group. (3+5)2023 January (Supplementary) (2019 Scheme)Short Essay · 8 marks
  3. 3Enumerate Antiemetics. Add a brief note on mechanism of action, uses and adverse effects of the most effective group. (3+3)2025 March (Supplementary (SAY)) (2019 Scheme)Short Essay · 6 marks
  4. 4Metoclopramide2022 May (Supplementary) (2010 Scheme)Short Note · 3 marks
  5. 5Ondansetron2019 February (2010 Scheme)Short Note · 3 marks
  6. 6Aprepitant2018 February (2010 Scheme)Short Note · 3 marks
  7. 7Ondansetron2024 August (Supplementary) (2010 Scheme)Short Note · 3 marks
  8. 8Domperidone2019 July (Supplementary) (2010 Scheme)Short Note · 3 marks
  9. 9Aprepitant2016 February (2010 Scheme)Short Answer · 1 mark
  10. 10Metoclopramide in vomiting.2025 March (Supplementary) (2010 Scheme)Short Answer · 1 mark
  11. 11Cinnarizine2023 July (Supplementary) (2010 Scheme)Short Answer · 1 mark
  12. 12Metoclopramide2023 March (Supplementary) (2010 Scheme)Short Answer · 1 mark
  13. 135HT3 Antagonist (eg. ondansetron) is used in Chemotherapy induced vomiting2023 March (Supplementary) (2010 Scheme)Short Answer · 1 mark
  14. 145HT antagonists2013 April (2010 Scheme)Short Answer · 1 mark
  15. 15Antiemetic agents2015 February (2010 Scheme)Short Answer · 1 mark
  16. 16Mechanism of action of metoclopramide2014 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  17. 17Vomiting2013 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
  18. 18Metoclopramide.2024 March (Supplementary) (2010 Scheme)Short Answer · 1 mark
  19. 19Motion sickness.2016 October (Supplementary) (2010 Scheme)Short Answer · 1 mark
  20. 20Domperidone in chemotherapy induced vomiting.2022 October (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  21. 21Antiemetics2021 February (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
  22. 22Cetirizine for motion sickness Name the following (Two examples for each): (8x1=8)2022 February (2019 Scheme)Short Answer · 0.2 marks
  23. 23Prokinetic agents.2023 July (Supplementary) (2019 Scheme)Short Answer · 0.2 marks

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