Paper II — 2025 March (Supplementary) (2010 Scheme) — Q8

Paper II

2025 March (Supplementary) (2010 Scheme)

Question

Metoclopramide in vomiting.

Q81 marksShort Answers★✓

Answer

Metoclopramide is a dopamine D2 receptor antagonist with prokinetic properties. It exerts its antiemetic effect through central D2 blockade at the chemoreceptor trigger zone (the same mechanism as other D2-antagonist antiemetics), while its additional 5-HT4 agonist/prokinetic action increases gastric emptying and lower esophageal sphincter tone — making it particularly useful for vomiting associated with delayed gastric emptying (diabetic gastroparesis, post-operative ileus) and GERD-related nausea, where a purely central antiemetic would not address the underlying motility component.

Related Concepts

1. 1Antiemetics

Other Years Asked

1. 1Enumerate Antiemetic drugs. Explain the Mechanism of action, uses and adverse effect of any one group. Briefly describe proton pump inhibitors (6+4+5)2024 June (Supplementary) (2019 Scheme)Essay · 15 marks
2. 2List three classes of Antiemetics. Write the mechanism of action, uses and adverse effects of the most effective Antiemetic group. (3+5)2023 January (Supplementary) (2019 Scheme)Short Essay · 8 marks
3. 3Enumerate Antiemetics. Add a brief note on mechanism of action, uses and adverse effects of the most effective group. (3+3)2025 March (Supplementary (SAY)) (2019 Scheme)Short Essay · 6 marks
4. 4Metoclopramide2022 May (Supplementary) (2010 Scheme)Short Note · 3 marks
5. 5Ondansetron2019 February (2010 Scheme)Short Note · 3 marks
6. 6Aprepitant2018 February (2010 Scheme)Short Note · 3 marks
7. 7Ondansetron2024 August (Supplementary) (2010 Scheme)Short Note · 3 marks
8. 8Metoclopramide2021 February (Supplementary) (2010 Scheme)Short Note · 3 marks
9. 9Domperidone2019 July (Supplementary) (2010 Scheme)Short Note · 3 marks
10. 10Aprepitant2016 February (2010 Scheme)Short Answer · 1 mark
11. 11Cinnarizine2023 July (Supplementary) (2010 Scheme)Short Answer · 1 mark
12. 12Metoclopramide2023 March (Supplementary) (2010 Scheme)Short Answer · 1 mark
13. 135HT3 Antagonist (eg. ondansetron) is used in Chemotherapy induced vomiting2023 March (Supplementary) (2010 Scheme)Short Answer · 1 mark
14. 145HT antagonists2013 April (2010 Scheme)Short Answer · 1 mark
15. 15Antiemetic agents2015 February (2010 Scheme)Short Answer · 1 mark
16. 16Mechanism of action of metoclopramide2014 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
17. 17Vomiting2013 September (Supplementary) (2010 Scheme)Short Answer · 1 mark
18. 18Metoclopramide.2024 March (Supplementary) (2010 Scheme)Short Answer · 1 mark
19. 19Motion sickness.2016 October (Supplementary) (2010 Scheme)Short Answer · 1 mark
20. 20Domperidone in chemotherapy induced vomiting.2022 October (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
21. 21Antiemetics2021 February (Supplementary) (2010 Scheme)Short Answer · 0.3 marks
22. 22Cetirizine for motion sickness Name the following (Two examples for each): (8x1=8)2022 February (2019 Scheme)Short Answer · 0.2 marks
23. 23Prokinetic agents.2023 July (Supplementary) (2019 Scheme)Short Answer · 0.2 marks