Paper II — 2023 March (Supplementary) (2010 Scheme) — Q9

Paper II

2023 March (Supplementary) (2010 Scheme)

Question

5HT3 Antagonist (eg. ondansetron) is used in Chemotherapy induced vomiting

Q91 marksShort Answers★✓

Answer

5-HT3 receptor antagonists block serotonin’s action both peripherally (at vagal afferents, where enterochromaffin cells release serotonin in response to chemotherapy-induced GI mucosal damage) and centrally at the chemoreceptor trigger zone. Because chemotherapy-induced nausea and vomiting involves both of these mechanisms simultaneously, blocking serotonin at both sites addresses the dominant pathway driving CINV specifically, making this class first-line — unlike other antiemetic classes that address only one component (e.g. D2 antagonists) or none of the serotonin-mediated pathway at all.

Related Concepts

1. 1Antiemetics

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